The 10/66 Dementia Research Group Population-Based Cohort Study
10/66 aims to provide a detailed evidence-base to inform the development and implementation of policies for improving the health and social welfare of older people in low and middle income countries, particularly the 14 million people with dementia, their relatives and carers.
The 10/66 population-based study aims to:
• Create a publicly accessible data archive;
• Use these data for comparative descriptive analyses of dementia prevalence, and its associated impact;
• Model dementia prevalence, examining the effects of age, education, literacy, socioeconomic status, urban vs rural setting, historical levels of infant mortality, economic development and industrialization;
• Estimate the annual incidence rate of dementia and its subtypes, by age group, education and centre, and to investigate risk factors for incident dementia and Alzheimer’s disease;
• Confirm the predictive validity of the survey dementia diagnoses and Mild Cognitive Impairment (MCI) through follow-up of all dementia and MCI cases.
- Start Year
- 2003
Visit 10/66
| Investigators | Contacts |
|---|---|
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Design
- Study design
- Population cohort
- Follow Up
- The first wave of surveys started in 2003. A first follow-up was carried out between 2007 and 2010 and the third wave of assessment using an extended form of the basic 10/66 survey will start in 2016. All the countries with the exception of urban India had a full follow-up. In India, a follow-up was only carried out for the mortality outcome.
- Supplementary Information
Marker Paper
A. Matthew Prina*, Daisy Acosta, Isaac Acostas, Mariella Guerra, YueqinHuang, AT Jotheeswaran, Ivonne Z. Jimenez-Velazquez, ZhaoruiLiu, Juan J LlibreRodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Martin Prince. (2016) CohortProfile: the 10/66 study. International Journal of Epidemiology. In press Prince, M., Ferri, C. P., Acosta, D., Albanese, E., Arizaga, R., Dewey, M., . . . Uwakwe, R. (2007). The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health, 7, 165. doi: 10.1186/1471-2458-7-165
PUBMED 17659078
Recruitment
- Sources of Recruitment
-
- Individuals
Number of participants
- Number of participants
- 15,901
- Number of participants with biosamples
- Supplementary Information
- By site, the numbers and proportions providing samples were: Cuba (2 355, 80.4% of those participating in the survey), Dominican Republic (1 483, 73.8%), Puerto Rico (1 584, 78.8%), Venezuela (1 284, 65.3%), urban Peru (755, 54.7%), urban Mexico (822, 82.0%), and rural Mexico (895, 89.5%)
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |
Availability of access information
On the study website : https://www.alz.co.uk/1066/
Timeline
Populations
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Cuba
- Territory
- One catchment area comprising sites in Havana and Matanzas
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 2,813
- Number of participants with biosamples
- 2,355
- Supplementary Information
- Baseline: 2813 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Cuba - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2003-11 | 2005-07 |
| 1 |
10/66 - Cuba - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2008-04 | 2010-05 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- India
- Territory
- Chennai
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 2,004
- Number of participants with biosamples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - India - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-03 | 2006-02 |
| 1 |
10/66 - India - Follow-up 1
|
Follow up was only carried out for the mortality outcome. For those who died between baseline and follow-up, a verbal autopsy interview with a co-resident, relative or other person ... |
2008-07 | 2008-09 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- China
- Territory
- Xicheng, Beijing province
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 1,160
- Number of participants with biosamples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Urban China - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-04 | 2004-12 |
| 1 |
10/66 - Urban China - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-05 | 2009-12 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- China
- Territory
- Daxing, Beijing province
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 1,002
- Number of participants with biosamples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Rural China - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-04 | 2005-02 |
| 1 |
10/66 - Rural China - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-07 | 2009-11 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Dominican Republic
- Territory
- Santo Domingo
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 2,011
- Number of participants with biosamples
- 1,483
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Venezuela
- Territory
- Caracas
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
Number of participants
- Number of participants
- 1,965
- Number of participants with biosamples
- 1,284
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Peru
- Territory
- Lima
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 1,381
- Number of participants with biosamples
- 755
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Urban Peru - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-03 | 2006-08 |
| 1 |
10/66 - Urban Peru - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-09 | 2010-07 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Peru
- Territory
- Canete Province
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 552
- Number of participants with biosamples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Rural Peru - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-12 | 2006-04 |
| 1 |
10/66 - Rural Peru - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-09 | 2009-12 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Mexico
- Territory
- Mexico city
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from existing studies
-
Number of participants
- Number of participants
- 1,003
- Number of participants with biosamples
- 822
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Urban Mexico - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-12 | 2007-03 |
| 1 |
10/66 - Urban Mexico - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-01 | 2010-05 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Mexico
- Territory
- Morelos State
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
Number of participants
- Number of participants
- 1,000
- Number of participants with biosamples
- 895
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Rural Mexico - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2006-08 | 2007-02 |
| 1 |
10/66 - Rural Mexico - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-08 | 2010-04 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Puerto Rico
- Territory
- Bayamon
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
Number of participants
- Number of participants
- 2,009
- Number of participants with biosamples
- 1,584
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Puerto Rico - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2007-08 | 2009-01 |
| 1 |
10/66 - Puerto Rico - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2012-05 | 2013-10 |