Individual Study / 10/66

The 10/66 Dementia Research Group Population-Based Cohort Study

The 10/66 Dementia Research Group Population-Based Cohort Study

10/66 logo
Initiatives -

10/66 aims to provide a detailed evidence-base to inform the development and implementation of policies for improving the health and social welfare of older people in low and middle income countries, particularly the 14 million people with dementia, their relatives and carers.

The 10/66 population-based study aims to:
• Create a publicly accessible data archive;
• Use these data for comparative descriptive analyses of dementia prevalence, and its associated impact;
• Model dementia prevalence, examining the effects of age, education, literacy, socioeconomic status, urban vs rural setting, historical levels of infant mortality, economic development and industrialization;
• Estimate the annual incidence rate of dementia and its subtypes, by age group, education and centre, and to investigate risk factors for incident dementia and Alzheimer’s disease;
• Confirm the predictive validity of the survey dementia diagnoses and Mild Cognitive Impairment (MCI) through follow-up of all dementia and MCI cases.

Start Year
2003
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Members

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Investigators Contacts
  • Dr Matthew Prina
    King's College London

Design

Study design
Population cohort
Follow Up
The first wave of surveys started in 2003. A first follow-up was carried out between 2007 and 2010 and the third wave of assessment using an extended form of the basic 10/66 survey will start in 2016. All the countries with the exception of urban India had a full follow-up. In India, a follow-up was only carried out for the mortality outcome.
Supplementary Information

Marker Paper

A. Matthew Prina*, Daisy Acosta, Isaac Acostas, Mariella Guerra, YueqinHuang, AT Jotheeswaran, Ivonne Z. Jimenez-Velazquez, ZhaoruiLiu, Juan J LlibreRodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Martin Prince. (2016) CohortProfile: the 10/66 study. International Journal of Epidemiology. In press Prince, M., Ferri, C. P., Acosta, D., Albanese, E., Arizaga, R., Dewey, M., . . . Uwakwe, R. (2007). The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health, 7, 165. doi: 10.1186/1471-2458-7-165

PUBMED 17659078

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
15,901
Number of participants with biosamples
Supplementary Information
By site, the numbers and proportions providing samples were: Cuba (2 355, 80.4% of those participating in the survey), Dominican Republic (1 483, 73.8%), Puerto Rico (1 584, 78.8%), Venezuela (1 284, 65.3%), urban Peru (755, 54.7%), urban Mexico (822, 82.0%), and rural Mexico (895, 89.5%)

Access

Availability of data and biosamples

Data
Biosamples
Other

Availability of access information

On the study website : https://www.alz.co.uk/1066/

Timeline

Populations

Participants are residents of Cuba, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Cuba
Territory
One catchment area comprising sites in Havana and Matanzas
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
2,813
Number of participants with biosamples
2,355
Supplementary Information
Baseline: 2813 participants
Data Collection Events
# Name Description Start End
0 10/66 - Cuba - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2003-11 2005-07
1 10/66 - Cuba - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2008-04 2010-05
Participants are residents of India, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • India
Territory
Chennai
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
2,004
Number of participants with biosamples
Data Collection Events
# Name Description Start End
0 10/66 - India - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2004-03 2006-02
1 10/66 - India - Follow-up 1

Follow up was only carried out for the mortality outcome.

For those who died between baseline and follow-up, a verbal autopsy interview with a co-resident, relative or other person ...

2008-07 2008-09
Participants are residents of urban China, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • China
Territory
Xicheng, Beijing province
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
1,160
Number of participants with biosamples
Data Collection Events
# Name Description Start End
0 10/66 - Urban China - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2004-04 2004-12
1 10/66 - Urban China - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2009-05 2009-12
Participants are residents of rural China, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • China
Territory
Daxing, Beijing province
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
1,002
Number of participants with biosamples
Data Collection Events
# Name Description Start End
0 10/66 - Rural China - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2004-04 2005-02
1 10/66 - Rural China - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2009-07 2009-11
Participants are residents of Dominican Republic, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Dominican Republic
Territory
Santo Domingo
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
2,011
Number of participants with biosamples
1,483
Participants are residents of Venezuela, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Venezuela
Territory
Caracas
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
1,965
Number of participants with biosamples
1,284
Participants are residents of urban Peru, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Peru
Territory
Lima
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
1,381
Number of participants with biosamples
755
Data Collection Events
# Name Description Start End
0 10/66 - Urban Peru - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2005-03 2006-08
1 10/66 - Urban Peru - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2009-09 2010-07
Participants are residents of rural Peru, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Peru
Territory
Canete Province
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
552
Number of participants with biosamples
Data Collection Events
# Name Description Start End
0 10/66 - Rural Peru - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2005-12 2006-04
1 10/66 - Rural Peru - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2009-09 2009-12
Participants are residents of urban Mexico, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Mexico
Territory
Mexico city
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
General Population
  • Selected sample
Participants from existing studies

Number of participants

Number of participants
1,003
Number of participants with biosamples
822
Data Collection Events
# Name Description Start End
0 10/66 - Urban Mexico - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2005-12 2007-03
1 10/66 - Urban Mexico - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2009-01 2010-05
Participants are residents of rural Mexico, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Mexico
Territory
Morelos State
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population

Number of participants

Number of participants
1,000
Number of participants with biosamples
895
Data Collection Events
# Name Description Start End
0 10/66 - Rural Mexico - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2006-08 2007-02
1 10/66 - Rural Mexico - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2009-08 2010-04
Participants are residents of Puerto Rico, age 65 years or older at the time of recruitment.
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Puerto Rico
Territory
Bayamon
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
2,009
Number of participants with biosamples
1,584
Data Collection Events
# Name Description Start End
0 10/66 - Puerto Rico - Baseline

Interview were generally carried out in participants’ own homes.

The information collected during the interview included measures of cognitive function, mental disorders, physical ...

2007-08 2009-01
1 10/66 - Puerto Rico - Follow-up 1

The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia.

The information collected during the interview included ...

2012-05 2013-10