Individual Study / 100+

The 100-plus Study

The 100-plus Study

Initiatives -
To identify the molecular characteristics associated with the delay or escape from cognitive decline, and Alzheimer’s Disease (AD) in particular. **alzheimercentrum@vumc.nl**
Start Year
2013
Visit 100+

Members

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Investigators Contacts
  • Dr. Prof. Henne Holstege
    Vrije Universiteit Amsterdam

Design

Study design
Population cohort
Follow Up
Baseline 2013: Centenarians are followed annually until death. The study initiated a second phase of the 100-plus Study in 2017: next to CHCs we include CHC‑partners, first-degree family members of CHCs and their respective partners, who are willing to participate.

Marker Paper

Holstege H, Beker N, Dijkstra T, et al. The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description. Eur J Epidemiol. 2018;33(12):1229-1249. doi:10.1007/s10654-018-0451-3

PUBMED 30362018

Recruitment

Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
500
Number of participants with biosamples
Supplementary Information
Dutch cognitively healthy centenarians

Access

Availability of data and biosamples

Data
Biosamples
Other