The 100-plus Study
Initiatives
-
To identify the molecular characteristics associated with the delay or escape from cognitive decline, and Alzheimer’s Disease (AD) in particular.
**alzheimercentrum@vumc.nl**
- Start Year
- 2013
Visit 100+
| Investigators | Contacts |
|---|---|
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Design
- Study design
- Population cohort
- Follow Up
- Baseline 2013: Centenarians are followed annually until death. The study initiated a second phase of the 100-plus Study in 2017: next to CHCs we include CHC‑partners, first-degree family members of CHCs and their respective partners, who are willing to participate.
Marker Paper
Holstege H, Beker N, Dijkstra T, et al. The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description. Eur J Epidemiol. 2018;33(12):1229-1249. doi:10.1007/s10654-018-0451-3
PUBMED 30362018
Recruitment
- Sources of Recruitment
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- Individuals
- Families
Number of participants
- Number of participants
- 500
- Number of participants with biosamples
- Supplementary Information
- Dutch cognitively healthy centenarians
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |