Initiative / Sentinel Initiative

Sentinel Initiative

Sentinel Initiative

Studies 14
Serve as a system to analyze and assess safety risks and effectiveness in FDA-approved(Food and Drug Administration) drugs and medical products using electronic health data.
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Investigators Contacts
  • Dr. Richard Platt
    Harvard Pilgrim Health Care Institute

General Information

Year created
2008
Types of cohorts
  • Population cohort
  • Patient/disease cohort
Countries
  • United States of America
Setting
National
Funding
Food and Drug Administration (FDA)
Criteria of cohort's to be included
Administrative databases. Selected electronic health record and laboratory test result data.
Health topic
  • Public health
  • General epidemiology
  • Biomedicine
Socio-environmental context
  • NA

Participants

Number of participants

Total
350,000,000
With harmonized data
350,000,000

Age range of the samples

Minimum age
0
Maximum age
100

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • Others
  • Type of infrastructure
    Data are in different locations
    Integrative data analysis
    • Meta-analyses
    Software
  • SAS
  • Other
  • Number of cohorts

    Total
    17
    With harmonized data
    17
    Will more cohorts be harmonized?

    Access

    Availability of metadata
    Availability of individual data

    Individual Studies

    Acronym Name Study design Participants Countries
    AETNA-CVS Aetna, a CVS Health company Patients' cohort
    BCBSMA Blue Cross Blue Shield of Massachusetts Patients' cohort 380,142
    CHR-Hawaii Kaiser Permanente Center for Integrated Health Care Research Hawaii Patients' cohort
    HealthCore, Inc (Anthem, Inc data) HealthCore, Inc (Anthem, Inc data) Patients' cohort
    HealthPartners Institute HealthPartners Institute Patients' cohort
    Kaiser Permanente Colorado Kaiser Permanente Colorado Population cohort 350,891
    Kaiser Permanente Northern California Kaiser Permanente Northern California Population cohort 350,891
    Kaiser Permanente Northwest Kaiser Permanente Northwest Population cohort 350,891
    KPWHRI-ACT Kaiser Permanente Washington Health Research Institute-Adult Changes in Thought (ACT) Patients' cohort 2,000
    MAPRI Kaiser Foundation Health Plan of the Mid-Atlantic States, Inc. Patients' cohort
    Marshfield Clinic Research Institute Marshfield Clinic Research Institute Patients' cohort
    Optum Optum (OptumInsight Life Sciences Inc. and Optum Labs®) Patients' cohort
    PopHealth DataShare PopHealth DataShare Patients' cohort
    Vanderbilt University Medical Center-Department of Health Policy (Tennessee Medicaid data) Vanderbilt University Medical Center(Tennessee Medicaid data) Patients' cohort