Initiative / ReACH

Research Advancement through Cohort Cataloguing and Harmonization
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Research Advancement through Cohort Cataloguing and Harmonization

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Studies 27
The aim of ReACH is to provide resources in the form of a comprehensive web-based catalogue and an harmonization platform to optimize and expand the use of Canadian pregnancy and birth cohorts data and biological samples.
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Members

Affiliated Members
Investigators Contacts
  • Dr. Isabel Fortier
    Research Institute of the McGill University Health Centre

General Information

Year created
2016
Types of cohorts
  • Population cohort
  • Patient/disease cohort
  • Clinical trial
Countries
  • Argentina
  • Australia
  • Belgium
  • Brazil
  • Canada
  • Chile
  • Croatia
  • Egypt
  • Estonia
  • Germany
  • Greece
  • Hungary
Region
Principally Canada
Setting
International
Funding
This project has received funding from the CIHR Operating Grant for the Canadian DoHaD Cohort Registry
Criteria of cohort's to be included
(1) recruit Canadian mothers and/or children; (2) have a longitudinal design (i.e. at least one follow-up of participants after the initial collection event); (3) have collected data (baseline or follow-up) after 2000; (4) collect information on pregnancy and birth outcomes
Health topic
  • Birth, infancy and childhood health
Socio-environmental context
  • NA

Participants

Number of participants

Total
89,889

Age range of the samples

Minimum age
0
Maximum age
45

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • Algorithmic
  • Calibration
  • Standardisation
  • Latent variable model
  • Multiple imputation
  • Others
    • Type of infrastructure
    Some centrally, other locally
    Integrative data analysis
    • Pooled analyses
    Software
  • OBiBa (Opal/Mica)
  • R / Rmarkdown
  • Other
    • Supplementary information
    The harmonisation will be achieved to serve the needs of a series of case studies. The strategies of harmonization are in some cohorts prospective and another retrospective.

    Number of cohorts

    Will more cohorts be harmonized?

    Access

    Availability of metadata
    Availability of individual data
    Under request

    Individual Studies

    Acronym Name Study design Participants Countries
    3D-Study Design, Develop, Discover Population cohort 2,366
    ABC Aboriginal Birth cohort Population cohort 686
    AOB/F All Our Families and All our babies Population cohort 6,774
    APrON Alberta Pregnancy Outcomes and Nutrition Population cohort 5,175
    CHILD Canadian Healthy Infant Longitudinal Development Study Population cohort 3,542
    EMIGARDE Life experiences and psychosocial development of the child: the role and quality of child care services Population cohort 1,030
    FAMILY Family Atherosclerosis Monitoring in Early Life Population cohort 1,000
    FPM Feelings in Pregnancy and Motherhood Population cohort 1,242
    GESTation and Environment Pregnancy and healthy child: a study of thyroid and environment Population cohort 1,561
    KFP Kids, Families and Places Population cohort 2,247
    MAVAN Maternal Adversity, Vulnerability and Neurodevelopment Population cohort 1,249
    MIREC Maternal-Infant Research on Environmental Chemicals Population cohort 2,000
    MIROS C Oxidative stress, fetal growth and programming of the metabolic syndrome and cardiovascular disorders Population cohort 614
    Mommybabyfmm Fort McMurray Mommy Baby Study Clinical trial 412
    OaK Birth Cohort Ottawa and Kingston Birth Cohort Population cohort 9,416
    OBS Ontario Birth Study Population cohort 2,748
    PE-NET Pre-Eclampsia New Emerging Team Case-control 460
    PIS Project Ice Storm Population cohort 100
    PreDICTR Prenatal Determinants of Inflammation - mediated Conditions Transdisciplinary Research Population cohort 65
    PreMarck Early Pregnancy Markers for Pre-Eclampsia Population cohort 2,119
    QLSCD Quebec Longitudinal Study of Child Development Population cohort 2,120
    QNTS Quebec Newborn Twin Study Population cohort 650
    SRI_Exposure Early child development and the effects of prenatal antidepressant exposure Population cohort 550
    START South Asian Birth Cohort Population cohort 1,500
    TARGet Kids! TARGet Kids! Population cohort 5,062
    TBS Twin Birth Study Clinical trial cohort 2,800
    SAGE Study of Asthma, Genes and the Environment Case-control 723