Initiative / LIFEPATH

Lifecourse biological pathways underlying social differences in healthy ageing

Lifecourse biological pathways underlying social differences in healthy ageing

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Studies 0
The overarching aim of the LIFEPATH project is to understand the determinants of diverging ageing pathways among individuals belonging to different socio-economic groups. This will be achieved via an original study design that integrates social science approaches with biology (including molecular epidemiology), using existing population cohorts and omics measurements (particularly epigenomics).
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Members

Investigators Contacts
  • Prof. Paolo Vineis
    Imperial College London

General Information

Year created
2015
Types of cohorts
  • Population cohort
Countries
  • United Kingdom
  • Ireland
  • Portugal
  • France
  • Switzerland
  • Italy
  • Finland
  • United States of America
  • Australia
Setting
International
Funding
This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Grant Agreement No. 633666
Criteria of cohort's to be included
LIFEPATH includes information and biological samples from 17 cohorts, including several with extensive phenotyping and repeat biological samples, and a very large cohort (1 million individuals) without biological samples (WHIP, from Italy). They were chosen for the combination of good measures of socioeconomic status, risk factors for non-communicable diseases (NCDs) and biomarkers already measured (or availability of blood samples for further testing).
Socio-environmental context
  • NA

Participants

Number of participants

Total
1,941,000
With harmonized data
102,774

Age range of the samples

Minimum age
0
Maximum age
150

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • NA
  • Type of infrastructure
    Some centrally, other locally
    Integrative data analysis
    • Meta-analyses
    • Pooled analyses
    Software
  • NA
  • Supplementary information
    More information: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503871/pdf/aging-11-101900.pdf https://www.pnas.org/content/pnas/suppl/2018/05/30/1800028115.DCSupplemental/pnas.1800028115.sapp.pdf

    Number of cohorts

    Total
    18
    With harmonized data
    8
    Will more cohorts be harmonized?
    Number of harmonized variables (max.)
    270

    Access

    Availability of metadata
    Availability of individual data