Initiative / Lifebrain

Lifebrain: Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts

Lifebrain: Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts

Studies 10
Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 5.000 individuals.
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Investigators Contacts
  • Prof. Kristine B. Walhovd
    Lifespan Changes in Brain and Cognition Research Group (LCBC), University of Oslo
  • Project email

General Information

Year created
2017
Types of cohorts
  • Population cohort
  • Patient/disease cohort
Countries
  • Norway
  • Denmark
  • Sweden
  • United Kingdom
  • Germany
  • Netherlands
  • Spain
Setting
International
Funding
Funded with 10 million EUR by the European Commission for 5 years, Horizon2020, Grant agreement no: 732592 - Lifebrain - H2020-SC1-2016-2017/H2020-SC1-2016-RTD.
Health topic
  • Ageing
  • Mental health
  • Public health
  • Neurological diseases
  • Genetics
  • Medical imaging
Socio-environmental context
  • Other : Socio-economic status (education, income)

Participants

Number of participants

Total
12,527
With harmonized data
5,000

Age range of the samples

Minimum age
0
Maximum age
90

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • Algorithmic
  • Calibration
  • Standardisation
  • Latent variable model
  • Multiple imputation
  • Type of infrastructure
    Data are centrally located
    Integrative data analysis
    • Pooled analyses
    • Other : We will use procedures developed and described by the BioSHaRE project for data harmonisation, integration and federated data analyses.
    Software
  • R / Rmarkdown
  • Other : FreeSurfer
  • Supplementary information
    Walhovd KB et al. Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”). European Psychiatry 50 (2018) 47–56. https://doi.org/10.1016/j.eurpsy.2017.12.006 https://www.sciencedirect.com/science/article/pii/S0924933817330237

    Number of cohorts

    Total
    11
    With harmonized data
    11
    Will more cohorts be harmonized?

    Access

    Availability of metadata
    Availability of individual data

    Individual Studies

    Acronym Name Study design Participants Countries
    Brain stimulation effects on cognitive function and mental health : University of Barcelona- BBSLab (unofficial name) Brain stimulation effects on cognitive function and mental health : University of Barcelona- BBSLab (unofficial name) Population cohort 261
    BASE I Berlin Aging Study I Population cohort 516
    BASE II Berlin Aging Study II Population cohort 2,200
    Betula - Aging, memory and dementia Betula - Aging, memory and dementia Population cohort 376
    CALM Cambridge Centre for Attention, Learning and Memory Population cohort 812
    Cam-CAN Cambridge Centre for Ageing and Neuroscience Population cohort 2,690
    Cognition and plasticity through the lifespan (LCBC) Cognition and plasticity through the lifespan (LCBC) Population cohort 1,677
    HUBU Danish Developmental studies - HUBU (“Hjernens Udvikling hos Børn og Unge“: Brain maturation in children and adolescents) Population cohort 94
    LISA Live Active Health Ageing Population cohort 450
    NESDA Netherlands Study of Depression and Anxiety Case-control 3,348