Initiative / IGEMS

Interplay of Genes and Environment across Multiple Studies

Interplay of Genes and Environment across Multiple Studies

IGEMS logo
Studies 16
The maing objective of the IGEMS is to understand why early life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life.
Investigators Contacts
  • Nancy Lee Pedersen
    University of Southern California (USC)

General Information

Year created
Types of cohorts
  • Population cohort
  • Sweden
  • Denmark
  • Finland
  • United States of America
  • Australia
National Institutes of Health Grants No. R01 AG037985, R56 AG037985, RF1 AG058068, R01 AG059329 and R01 AG060470.
Criteria of cohort's to be included
Cohorts involving twins with measures of physical health, cognitive health and emotional health, and measures of multiple facets of adult socioeconomic status (SES; e.g.occupation, education, financial strain)
Socio-environmental context
  • Environmental hazards
  • Work-related stress


Number of participants

With harmonized data

Age range of the samples

Minimum age
Maximum age

Methodology for harmonization and integration

Strategy of harmonization
Data processing methods
  • Algorithmic
  • Calibration
  • Standardisation
  • Latent variable model
  • Type of infrastructure
    Some centrally, other locally
    Integrative data analysis
    • Meta-analyses
    • Pooled analyses
  • R / Rmarkdown
  • Stata
  • SAS
  • Other
  • Supplementary information
    Harmonization has been done for specific analyses. Some research papers: - -

    Number of cohorts

    With harmonized data
    Will more cohorts be harmonized?
    Number of harmonized variables (max.)


    Availability of metadata
    Under request
    Availability of individual data

    Individual Studies

    Acronym Name Study design Participants Countries
    CAATSA Carolina African-American Twin Study of Aging Population cohort 572
    FT16 FinnTwin16 Population cohort 3,215
    FTC The finish twin cohort Population cohort 14,000
    GENDER Aging in Women and Men Population cohort 1,210
    LSADT Longitudinal Study of Aging Danish Twins Population cohort 4,731
    MADT Study of Middle-Aged Danish Twins Population cohort 4,314
    MIDT MId-aged Danish Twins (MIDT) Population cohort 14,000
    MIDUS Midlife in the United States Twin Study Population cohort 3,621
    MTSADA Minnesota Twin Study of Adult Development and Aging Population cohort 810
    NAS-NRC Twin Registry and Duke Twins Study Population cohort 15,924
    OATS Older Australian Twin Study Population cohort 599
    OCTO-Twin Study of Origins of Variance in the Old-Old Population cohort 702
    PTTS Project Talent Twin and Sibling Study Population cohort 4,481
    SATSA Swedish Adoption/Twin Study of Aging Population cohort 2,000
    TOSS Twin Offspring Study in Sweden Population cohort 3,000
    VETSA Vietnam-Era Twin Study of Aging Population cohort 1,237