Initiative / IGEMS

Interplay of Genes and Environment across Multiple Studies

Interplay of Genes and Environment across Multiple Studies

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Studies 0
The maing objective of the IGEMS is to understand why early life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life.
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Members

Investigators Contacts
  • Nancy Lee Pedersen
    University of Southern California (USC)

General Information

Year created
2012
Types of cohorts
  • Population cohort
Countries
  • Sweden
  • Denmark
  • Finland
  • United States of America
  • Australia
Setting
International
Funding
National Institutes of Health Grants No. R01 AG037985, R56 AG037985, RF1 AG058068, R01 AG059329 and R01 AG060470.
Criteria of cohort's to be included
Cohorts involving twins with measures of physical health, cognitive health and emotional health, and measures of multiple facets of adult socioeconomic status (SES; e.g.occupation, education, financial strain)
Socio-environmental context
  • Environmental hazards
  • Work-related stress

Participants

Number of participants

Total
76,233
With harmonized data
76,233

Age range of the samples

Minimum age
14
Maximum age
103

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • Algorithmic
  • Calibration
  • Standardisation
  • Latent variable model
  • Type of infrastructure
    Some centrally, other locally
    Integrative data analysis
    • Meta-analyses
    • Pooled analyses
    Software
  • R / Rmarkdown
  • Stata
  • SAS
  • Other
  • Supplementary information
    Harmonization has been done for specific analyses. Some research papers: - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833715/ - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706656/

    Number of cohorts

    Total
    18
    With harmonized data
    18
    Will more cohorts be harmonized?
    Number of harmonized variables (max.)
    31

    Access

    Availability of metadata
    Under request
    Availability of individual data