Initiative / I4C

International Childhood Cancer Cohort Consortium
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International Childhood Cancer Cohort Consortium

Studies 6
The aim of I4C is to understand the aetiology and mechanistic underpinnings of childhood cancer by exploiting prospectively collected exposure and biomarker data. A summary is provided in the publication - 'The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers' at the following link - https://onlinelibrary.wiley.com/doi/full/10.1111/ppe.12519
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Members

Affiliated Members
Investigators Contacts
  • Gabriella Tikellis
  • Terry Dwyer

General Information

Year created
2004
Types of cohorts
  • Population cohort
Countries
  • Australia
  • Denmark
  • Brazil
  • China
  • France
  • Italy
  • Israel
  • Japan
  • Norway
  • United Kingdom
  • United States of America
Setting
International
Funding
NA
Criteria of cohort's to be included
Cohorts eligible for inclusion in the I4C need to recruit mothers during pregnancy or around delivery. Eligible cohorts must systematically ascertain cases of CC in the offspring and should include questionnaire and/or other exposure data that address key CC aetiology-related hypotheses. The specific goals and original outcomes of the individual cohorts (eg, pregnancy complications and/ or serious chronic childhood conditions) may vary, but critical data items include parental and offspring demographic, life style, medical, reproductive, environmental factors and parental occupational information. Specific responsibilities of newly joining or participating I4C cohorts include sharing of data (and biospecimens-if available) for current and future proposals.
Health topic
  • Birth, infancy and childhood health
  • Cancer
Socio-environmental context
  • NA

Participants

Number of participants

Total
388,120

Age range of the samples

Minimum age
0
Maximum age
30

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • NA
    • Type of infrastructure
    Some centrally, other locally
    Integrative data analysis
    • Pooled analyses
    Software
  • NA
    • Supplementary information
    https://www.mcri.edu.au/research/projects/international-childhood-cancer-cohortconsortium-i4c

    Number of cohorts

    Total
    6
    With harmonized data
    6
    Will more cohorts be harmonized?
    Number of harmonized variables (max.)
    20

    Access

    Availability of metadata
    Availability of individual data

    Individual Studies

    Acronym Name Study design Participants Countries
    ALSPAC Avon Longitudinal Study of Parents and Children Population cohort 14,541 United Kingdom
    CPP Collaborative Perinatal Project Population cohort 50,000
    DNBC Danish National Birth Cohort Population cohort 101,042
    JPS Jerusalem Perinatal Study (JPS) Population cohort 92,408
    MoBa Norwegian Mother and Child Cohort Study Population cohort 285,200
    TAHS Tasmanian Infant Health Study (TAHS) Population cohort 7,380