Initiative / GEMRIC

Global ECT-MRI Research Collaboration

Global ECT-MRI Research Collaboration

Studies 14
GEMRIC is a Global network and research collaboration for projects focused on determining the mechanisms of action of Electroconvulsive Therapy using Magnetic Resonance Imaging. GEMRIC has a board consisting of lead researchers (e.g. PIs) from projects/studies that are participating in the collaboration. We are creating a large database of multi-site imaging data and clinical/behavioral/physiological and metadata for analysis of the neural mechanisms and predictors of electroconvulsive therapyrelated clinical response.
Investigators Contacts
  • Dr. Prof. Leif Oltedal
    University of Bergen

General Information

Year created
Types of cohorts
  • Patient/disease cohort
  • Japan
  • United States of America
  • Norway
  • Switzerland
  • Belgium
  • Netherlands
  • Denmark
  • Germany
  • Spain
  • France
  • Austria
  • Ireland
Western Europe
The centralized data infrastructure and study co-ordination is supported by Western Norway Regional Health Authority, Haukeland University Hospital and the University of Bergen, Norway.
Criteria of cohort's to be included
Projects that are investigating the mechanisms of action of ECT can participate in GEMRIC and contribute with data to a common analysis platform. Studies that included imaging measurements before and after electroconvulsive therapy.
Health topic
  • Mental health
  • Medical imaging
  • Other : Electroconvulsive Therapy (ECT)


Number of participants

With harmonized data

Age range of the samples

Minimum age
Maximum age

Methodology for harmonization and integration

Strategy of harmonization
Data processing methods
  • Algorithmic
  • Others
  • Type of infrastructure
    Data are centrally located
    Integrative data analysis
    • Pooled analyses
    • Other : Mega-analysis (pooled individual data meta-analysis)
  • R / Rmarkdown
  • SPSS
  • Other : Various neuroimaging tools
  • Supplementary information
    Oltedal L et al. The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy.Neuroimage Clin. 2017 Feb 14;14:422-432. doi: 10.1016/j.nicl.2017.02.009. eCollection 2017

    Number of cohorts

    With harmonized data
    Will more cohorts be harmonized?


    Availability of metadata
    Availability of individual data

    Individual Studies

    Acronym Name Study design Participants Countries
    Abbott_Transl Psychiatry_2014 Hippocampal structural and functional changes associated with electroconvulsive therapy response (The GEMRIC Albuquerque, NM USA center) Patients' cohort 41
    Argyelan_Transl Psychiatry_2016 Subgenual cingulate cortical activity predicts the efficacy of electroconvulsive therapy (The GEMRIC Glen Oaks, NY, USA center) Patients' cohort 23
    Beal_J ECT_2012 Effects of electroconvulsive therapy on brain functional activation and connectivity in depression (The GEMRIC Cleveland, OH, USA center) Patients' cohort 6
    Bouckaert_J Psychiatry Neurosci_2016 Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study (The GEMRIC Leuven, Belgium center) Patients' cohort 28
    Dols_Am J Geriatr Psychiatry_2017 Early- and late-onset depression in late life: A prospective study on clinical and structural brain characteristics and response to Electroconvulsive Therapy (The GEMRIC Amsterdam, the Netherlands center) Patients' cohort 110
    Dukart_Proc Natl Acad Sci USA_2014 Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders (The GEMRIC centers in Lausanne, Switzerland and Berlin, Germany) Patients' cohort 10
    Jorgensen_Acta Psychiatr Scand_2016 Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression (The GEMRIC Copenhagen, Denmark center) Patients' cohort 19
    Joshi_Biol Psychiatry_2016 Structural plasticity of the hippocampus and amygdala induced by Electroconvulsive Therapy in major depression (The GEMRIC LosAngeles, CA, USA center) Patients' cohort 43
    Nordanskog_J ECT_2010 Increase in hippocampal volume after electroconvulsive therapy in patients with depression: a volumetric magnetic resonance imaging study (The GEMRIC Lund, Sweden center) Patients' cohort 12
    Oltedal_BMC Psychiatry_2015 Effects of ECT in treatment of depression: study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function (The GEMRIC Bergen, Norway center) Patients' cohort 40
    Redlich_JAMA Psychiatry_2016 Prediction of individual response to Electroconvulsive Therapy via machine learning on structural Magnetic Resonance Imaging data (The GEMRIC Munster, Germany center) Patients' cohort 28
    The GEMRIC Linköping, Sweden center The GEMRIC Linköping, Sweden center Patients' cohort 11
    The GEMRIC Utrecht, the Netherlands center The GEMRIC Utrecht, the Netherlands center Patients' cohort 37
    van Eijndhoven_Transl Psychiatry_2016 Bilateral ECT induces bilateral increases in regional cortical thickness (The GEMRIC Nijmegen, the Netherlands center) Patients' cohort 45