Initiative / COSMIC

COSMIC: Cohort Studies of Memory in an International Consortium

COSMIC: Cohort Studies of Memory in an International Consortium

Studies 40
Harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.
Investigators Contacts
  • Dr. Prof. Perminder Sachdev
    Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney
  • Dr. Darren Lipnicki
    Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney

General Information

Year created
Types of cohorts
  • Population cohort
  • Australia
  • Brazil
  • Canada
  • Central African Republic
  • China
  • Cuba
  • Ecuador
  • United Kingdom
  • Faroe Islands
  • France
  • Germany
  • Greece
  • Indonesia
  • Hong Kong
  • India
  • Iran
  • Italy
  • Japan
  • Malaysia
  • Nigeria
  • Philippines
  • Puerto Rico
  • Congo, the Democratic Republic of the
  • Singapore
  • South Korea
  • Spain
  • Sweden
  • Taiwan
  • Tanzania
  • Netherlands
  • United States of America
Worldwide (31 countries across 6 continents)
US$2.57 million from the National Institutes of Health, USA from 2017 to 2022.
Criteria of cohort's to be included
Studies participating in COSMIC typically meet the following membership criteria: 1. Are epidemiological, and therefore population-based. 2. Examine individuals aged 60 years and over. 3. Are longitudinal, either with follow-up assessments or intending to have these. 4. Include an assessment of cognitive function, cognitive impairment or dementia as an important, if not central, objective. Studies from Africa, South America, Eastern Europe and under-represented areas in Asia are particularly encouraged to join (and whom not all membership criteria necessarily need to be met).
Health topic
  • Ageing
  • Mental health
  • Neurological diseases


Number of participants

With harmonized data

Age range of the samples

Minimum age
Maximum age

Methodology for harmonization and integration

Strategy of harmonization
Data processing methods
  • Standardisation
  • Type of infrastructure
    Data are centrally located
    Integrative data analysis
    • Meta-analyses
    • Pooled analyses
  • Stata
  • SPSS
  • Supplementary information
    Sachdev, Perminder S., et al. "COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups." BMC neurology 13.1 (2013): 165. Lipnicki, Darren M et al. “Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study.” PLoS medicine vol. 16,7 e1002853. 23 Jul. 2019, doi:10.1371/journal.pmed.1002853

    Number of cohorts

    With harmonized data
    Will more cohorts be harmonized?


    Availability of metadata
    Under request
    Availability of individual data
    Under request

    Individual Studies

    Acronym Name Study design Participants Countries
    DMS De Maastricht Studie Patients' cohort 10,000
    CFAS Cognitive Function and Ageing Study (CFAS) Population cohort 13,004
    PATH Personality and Total Health through life Population cohort 2,551
    SCS Sydney Centenarian Study Population cohort 300
    BCSA Bambui Cohort Study of Aging Population cohort 1,606
    BEH Bushehr Elderly Health Program Population cohort 3,000
    CHAS Cuban Health and Alzheimer Study Population cohort 2,944
    CLAS Chinese Longitudinal Aging Study Population cohort 3,514
    CSHA Canadian Study of Health and Aging Population cohort 10,000
    EAS Einstein Aging Study Population cohort 2,000
    EPIDEMCA Epidemiology of Dementia in Central Africa Patients' cohort 2,002
    ESPRIT Etude Santé Psychologique Prévalence Risques et Traitement Population cohort 2,268
    H70 Gothenburg H70 Birth Cohort Studies Population cohort 3,563
    HELIAD Hellenic Longitudinal Investigation of Aging and Diet Population cohort 1,050
    Hendrie_JAMA_2001 The Indianapolis Ibadan Dementia Project Population cohort 2,459
    Hisayama Study Hisayama Study Population cohort 6,983
    HK-MAPS Hong Kong Memory and Ageing Prospective Study Population cohort 787
    IDEA Identification and Intervention for Dementia in Elderly Africans Study Population cohort 473
    ILAS I-Lan Longitudinal Aging Study Population cohort 532
    Invence.Ab Invecchiamento Cerebrale in Abbiategrasso Population cohort 1,321
    Ishizaki_J Gerontol B Psychol Sci Soc Sci_1998 Osaki-Tajiri Project Population cohort 2,266
    KLOSCAD Korean Longitudinal Study on Cognitive Aging and Dementia Population cohort 7,000
    Kurihara Project Kurihara Project Population cohort 590
    LEILA75+ Leipzig Longitudinal Study of the Aged Population cohort 1,265
    LRGS TUA Neuroprotective Model for Healthy Longevity among Malaysian Older Adults Population cohort 2,322
    MMAP Marikina Memory and Aging Project Population cohort 1,460
    MoVIES Monongahela Valley Independent Elders Survey Population cohort 1,681
    MYNAH MYsore studies of Natal effects on Ageing and Health Population cohort 517
    MYHAT Monongahela-Youghiogheny Healthy Aging Team Population cohort 1,982
    PREHCO Puerto Rican Elderly: Health Conditions study Population cohort 3,891
    SALSA Sacramento Area Latino Study on Aging Population cohort 1,789
    SGS Sasaguri Genkimon Study Population cohort 1,977
    Shanghai Aging Study Shanghai Aging Study Population cohort 3,141
    SLAS I & II Singapore Longitudinal Ageing Studies Population cohort 6,183
    SPAH São Paulo Ageing & Health Study Population cohort 2,072
    The Maastricht AF-CT cohort The Maastricht AF-CT cohort Case-control 388
    Turana_Int J Alz Dis_2014 Study on quality of life in elderly in Kali Anyar, West Jakarta Population cohort 109
    WHICAP Washington Heights Inwood and Columbia Aging Project Population cohort 2,126
    ZARADEMP ZARAgoza DEMentia DEPression Project Population cohort 4,803
    MAS Sydney Memory & Ageing Study Population cohort 1,037