Initiative / COSMIC

COSMIC: Cohort Studies of Memory in an International Consortium

COSMIC: Cohort Studies of Memory in an International Consortium

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Studies 0
Harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.
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Members

Investigators Contacts
  • Prof. Perminder Sachdev
    Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney
  • Dr. Darren Lipnicki
    Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney

General Information

Year created
2013
Types of cohorts
  • Population cohort
Countries
  • Australia
  • Brazil
  • Canada
  • Central African Republic
  • China
  • Cuba
  • Ecuador
  • United Kingdom
  • Faroe Islands
  • France
  • Germany
  • Greece
  • Indonesia
  • Hong Kong
  • India
  • Iran
  • Italy
  • Japan
  • Malaysia
  • Nigeria
  • Philippines
  • Puerto Rico
  • Congo, the Democratic Republic of the
  • Singapore
  • South Korea
  • Spain
  • Sweden
  • Taiwan
  • Tanzania
  • Netherlands
  • United States of America
Region
Worldwide (31 countries across 6 continents)
Setting
International
Funding
US$2.57 million from the National Institutes of Health, USA from 2017 to 2022.
Criteria of cohort's to be included
Studies participating in COSMIC typically meet the following membership criteria: 1. Are epidemiological, and therefore population-based. 2. Examine individuals aged 60 years and over. 3. Are longitudinal, either with follow-up assessments or intending to have these. 4. Include an assessment of cognitive function, cognitive impairment or dementia as an important, if not central, objective. Studies from Africa, South America, Eastern Europe and under-represented areas in Asia are particularly encouraged to join (and whom not all membership criteria necessarily need to be met).

Participants

Number of participants

Total
121,000
With harmonized data
49,000

Age range of the samples

Minimum age
60
Maximum age
105

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • Standardisation
  • Type of infrastructure
    Data are centrally located
    Integrative data analysis
    • Meta-analyses
    • Pooled analyses
    Software
  • Stata
  • SPSS
  • Supplementary information
    Sachdev, Perminder S., et al. "COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups." BMC neurology 13.1 (2013): 165. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827845/pdf/1471-2377-13-165.pdf Lipnicki, Darren M et al. “Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study.” PLoS medicine vol. 16,7 e1002853. 23 Jul. 2019, doi:10.1371/journal.pmed.1002853

    Number of cohorts

    Total
    41
    With harmonized data
    20
    Will more cohorts be harmonized?

    Access

    Availability of metadata
    Under request
    Availability of individual data
    Under request