Initiative / CNODES

CNODES: the Canadian Network for Observational Drug Effect Studies

CNODES: the Canadian Network for Observational Drug Effect Studies

Studies 8
Use collaborative, population-based approaches to obtain rapid answers to questions about drug safety and effectiveness.
Visit CNODES
Investigators Contacts
  • Methods team
  • Coordination centre
  • Dr. Robert Platt
    Canadian Institutes of Health Research (CIHR)

General Information

Year created
2011
Types of cohorts
  • Population cohort
  • Patient/disease cohort
Countries
  • Canada
  • United States of America
  • United Kingdom
Setting
International
Funding
Funded by Health Canada and the CIHR.
Criteria of cohort's to be included
Administrative health data sources.
Health topic
  • Biomedicine

Participants

Number of participants

Total
100,000,000

Age range of the samples

Minimum age
0

Methodology for harmonization and integration

Strategy of harmonization
Ex-post
Data processing methods
  • NA
  • Type of infrastructure
    Data are in different locations
    Integrative data analysis
    • Meta-analyses
    • Pooled analyses
    Software
  • R / Rmarkdown
  • SAS
  • Supplementary information
    Suissa et al. CNODES: the Canadian Network for Observational Drug Effect Studies. Open Medicine 2012;6(4)e134 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654509/

    Number of cohorts

    Total
    9
    With harmonized data
    9
    Will more cohorts be harmonized?
    Number of harmonized variables (max.)
    100

    Access

    Availability of metadata
    Under request
    Availability of individual data

    Individual Studies

    Acronym Name Study design Participants Countries
    CPRD Clincal Practice Research Datalink Patients' cohort 60,000,000
    IBM MarketScan Research Databases IBM MarketScan Research Databases Patients' cohort 250,000,000
    Suissa_Open Med_2012 British Columbia provincial database Patients' cohort 4,573
    Suissa_Open Med_2012 Saskatchewan provincial database Patients' cohort 1,908
    Suissa_Open Med_2012 Manitoba provincial database Patients' cohort 1,251
    Suissa_Open Med_2012 Ontario provincial database Patients' cohort 13,373
    Suissa_Open Med_2012 Quebec provincial database Patients' cohort 7,980
    Suissa_Open Med_2012 Nova Scotia Patients' cohort 945