Breast CAncer Stratification (B-CAST): Understanding the determinants of risk and prognosis of molecular breast cancer subtypes
In B-CAST the overall goal is to investigate the determinants of the development of specific breast cancer subtypes, and subsequent prognosis. Models and tools will be developed to allow identification of the individual risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. The specific project objectives are: * To define the influence of risk factors, including reproductive history, lifestyle, mammographic breast density and germline genetic variation, on breast cancer overall and by subtypes characterized by clinical and molecular markers. * To define the influence of risk factors and tumour subtypes on clinical prognosis. * To develop and validate breast cancer risk and prognostication models for breast cancer, overall and by subtypes, informed by knowledge acquired under above objectives * To implement these models into online tools for risk prediction and prognostication; and make them available in multiple countries/languages. * To raise awareness, i.e. promote the development and integration of personalized breast cancer prevention within national public health programmes..
- Types of cohorts
- Patient/disease cohort
- United States of America
- Europe, Asia
- This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 633784
- Criteria of cohort's to be included
- For B-CAST includes invasive breast cancer cases of studies participating in the Breast Cancer Association Consortium (BCAC). Studies that wish to participate in the DNA panel sequencing effort of B-CAST (~10,000 tumours) needed to have ethical approval that includes targeted DNA sequencing of germline and tumour DNA, and have core data available and genotyping data from iCOGS, OncoArray or GWAS.
- Health topic
- General epidemiology
- Socio-environmental context
- With harmonized data
Methodology for harmonization and integration
- Strategy of harmonization
- Type of infrastructure
- Some centrally, other locally
- Integrative data analysis
- Pooled analyses
- Supplementary information
- This is an initiative departing from the Breast Cancer Association Consortium (BCAC), which is one of the members of the COGS consortium.
- With harmonized data